Etizolam Powder

Etizolam Powder is a potent thienodiazepine analog that exhibits pharmacological properties similar to classical benzodiazepines. Available as a fine, crystalline research-grade powder, Etizolam is commonly used in laboratories and academic research for the study of GABAergic system interactions, receptor binding affinity, and central nervous system depressant effects.

Originally developed in Japan, Etizolam differs structurally from traditional benzodiazepines by replacing the benzene ring with a thiophene ring, making it part of the thienodiazepine class. It is known for its rapid onset, short half-life, and high potency, and is often researched in the context of its anxiolytic, sedative, muscle relaxant, and anticonvulsant profiles.

This compound is strictly intended for laboratory use only and is not for human consumption. It is important for all researchers and institutions to ensure compliance with their local regulations, as Etizolam’s legal status varies by country.

• Chemical Name: Etizolam (6-(2-chlorophenyl)-1-methyl-8-thioxo-4H-s-triazolo[4,3-a][1,4]benzodiazepine)

• Molecular Formula: C17H15ClN4S

• Form: Fine crystalline powder

• Purity: ≥99% (HPLC-tested)

• Use: Research and forensic analysis only

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🧪 Etizolam Powder: Uses, Properties & Manufacturing Process

🔹 Uses of Etizolam Powder

Etizolam Powder is primarily used in scientific, pharmacological, and forensic research. As a synthetic thienodiazepine, it is structurally and functionally similar to benzodiazepines, with distinct differences that make it valuable in receptor binding studies and CNS pharmacodynamics research.

✅ Common Applications:

1. Pharmacological Studies – Investigating GABA-A receptor agonism, anxiolytic and hypnotic activity.

2. Toxicology Testing – Used as a reference standard in forensic toxicology labs.

3. Neuropharmacology Research – Studying mechanisms of action involving sedation, muscle relaxation, and seizure threshold modulation.

4. Analytical Method Development – Calibration and validation of HPLC, GC-MS, and LC-MS analytical methods.

5. Forensic Chemistry – Detection and quantification in biological samples during post-mortem or intoxication investigations.

🔹 Chemical & Physical Properties of Etizolam Powder

🔹 Manufacturing Process of Etizolam Powder

⚗️ Step-by-Step Overview (Simplified & Educational):

1. Preparation of Core Benzodiazepine Intermediate

   • The process begins with a 2-chlorobenzoyl derivative and an o-phenylenediamine to form the benzodiazepine nucleus.

   • Reaction typically involves condensation and cyclization steps under controlled temperatures.

2. Thienodiazepine Conversion

   • A thiophene or thioamide group is introduced via substitution reactions to form the thienodiazepine ring system, a key structural difference from traditional benzodiazepines.

3. Triazole Ring Formation

   • A 1,2,4-triazole ring is added by reacting with hydrazine derivatives, usually in acidic or catalytic environments, forming the triazolobenzodiazepine skeleton unique to Etizolam.

4. Final Methylation & Purification

   • Methylation at the nitrogen atom improves bioactivity and receptor binding.

   • The final product undergoes recrystallization, chromatographic purification, and HPLC testing to ensure ≥99% purity.

5. Quality Control & Packaging

   • The compound is tested for:

     • Purity (HPLC, GC-MS)

     • Moisture content

     • Residual solvents

     • Structural confirmation (NMR, IR, MS)

   • Packaged in airtight, light-resistant containers, labeled with batch number, purity, and storage instructions.

⚠️ Legal & Regulatory Considerations

• Controlled Status:

  • USA: Not FDA-approved; listed as Schedule I in some states.

  • EU: Controlled or prescription-only in many countries.

  • Japan & India: Approved for medical use under prescription (as Depas, Etizest, etc.).

• For Research Only:

  • Must not be used for recreational purposes, human testing, or veterinary use.

  • Researchers should follow all institutional, local, and international laws regarding possession and handling.

📌 Summary

Etizolam Powder is a research-grade chemical compound widely studied for its benzodiazepine-like activity on the central nervous system. With precise manufacturing protocols and stringent lab testing, it remains a key tool in the development of analytical methods, receptor binding studies, and forensic toxicology research. Its synthesis, possession, or use outside approved contexts is strictly prohibited.

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