3-4-MD-A-PBP

3′,4′-MD-a-PBP

3′,4′-MD-a-PBP, also known as 3,4-Methylenedioxy-alpha-pyrrolidinobutyrophenone, is a synthetic stimulant and cathinone analog that belongs to the pyrrolidinophenone class of compounds. It features a methylenedioxy functional group on the phenyl ring, structurally aligning it with research chemicals like MDPV, α-PBP, and α-PVP. This compound is commonly used in forensic, neurochemical, and pharmacological research, especially in studies examining dopamine and norepinephrine transporter inhibition and structure-activity relationships (SARs) in substituted cathinones.

In laboratory settings, 3,4-MD-a-PBP is valued for its stability, purity, and well-defined molecular structure, making it a reliable subject for mass spectrometry, chromatographic calibration, and in vitro assays. Researchers may also use it to develop analytical techniques for identifying emerging synthetic substances in toxicology or drug screening panels.⚠️

🔬 Specifications (Example Only):

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Uses (Research & Analytical Context)

3,4‑MD‑α‑PBP is used primarily as a research/analytical standard and a subject in forensic, pharmacological, and structure–activity relationship (SAR) studies. Typical legitimate applications include: development and validation of GC‑MS/LC‑MS and chromatographic screening methods for novel psychoactive substances (NPS), toxicology reference material in forensic laboratories, in‑vitro investigations of transporter and receptor interactions (dopamine/norepinephrine/serotonin systems) under controlled institutional protocols, and comparative SAR work to better understand potency, metabolism, and toxicological profiles of substituted cathinones/pyrrolidinophenones. It may also be used in stability and degradation studies relevant to detection and evidence preservation.

Key Physical & Chemical Properties

• Chemical class: Pyrrolidinophenone (α‑pyrrolidinobutyrophenone derivative) with a 3,4‑methylenedioxy substitution on the phenyl ring.

• Approx. molecular formula: C15H19NO3 (literature values vary with tautomeric/hydration states)

• Approx. molecular weight: ~261 g·mol⁻¹

• Appearance: Off‑white to pale crystalline powder (laboratory batches vary)

• Solubility: Soluble in common organic solvents (ethanol, methanol, DMSO); limited aqueous solubility — typically handled as freebase or salt forms depending on application.

• Stability & storage: Relatively stable when stored dry, protected from light and moisture at low temperature; hygroscopic or degradable under harsh conditions—store in sealed, labeled containers per institutional SOPs.

• Analytical characteristics: Readily characterized/confirmed by NMR (1H/13C), GC‑MS/LC‑MS, IR, and HPLC; retention times, fragmentation patterns and spectral data are used as reference signatures in forensic databases.

• Pharmacology (research context): Exhibits stimulant‑type activity in vitro similar to other pyrrolidinophenone cathinones; interacts with monoamine transporters, though potency, selectivity, and in vivo effects vary and must be established experimentally under ethical protocols.

• Hazards: May have stimulant‑related toxicological risks (cardiovascular, CNS overstimulation, neurotoxicity) and should be handled with caution. Use appropriate PPE and engineering controls.

Manufacturing Overview (Non‑Actionable, High Level)

The preparation of complex substituted pyrrolidinophenones is accomplished by multi‑step synthetic organic chemistry in properly equipped, licensed laboratories. A high‑level conceptual outline (no procedural detail, no conditions, and no reagent lists) is provided below for academic understanding only:

• Precursor selection: The chemistry is typically built from an appropriately substituted aromatic / aryl ketone or related precursor bearing the 3,4‑methylenedioxy moiety to provide the target phenyl ring substitution pattern.

• Construction of the α‑carbonyl framework: Organic transformations are used to install and elaborate the α‑carbonyl (butyrophenone) backbone—this commonly involves carbon‑carbon bond‑forming steps and modifications of the ketone side chain.

• Introduction of the pyrrolidine moiety: The pyrrolidine ring (the “pyrrolidino” group) is incorporated to form the α‑pyrrolidinobutyrophenone structural motif; this step converts a primary/secondary amine functionality into the cyclic tertiary amine present in pyrrolidinophenones.

• Purification & salt formation: After assembly, the crude product is purified by chromatographic and/or recrystallization methods appropriate to analytical‑grade materials; when required for handling and solubility, the freebase can be converted to a salt form and isolated as a crystalline material.

• Characterization & QA/QC: Final material is characterized by 1H/13C NMR, MS, IR, and HPLC/GC and quantified for purity. Batch records, certificates of analysis (COA), and chain‑of‑custody documentation are maintained in regulated labs.

• Regulatory & safety controls: Synthesis and possession are subject to local and national laws; production must only occur in licensed facilities with institutional approvals, hazardous waste management, and full compliance with chemical safety and controlled‑substances regulations.

Safety, Legal & Ethical Considerations

• Not for human consumption: This compound is for in vitro/in vivo research only in regulated, approved studies; it is not for therapeutic or recreational use.

• Controlled status: Many jurisdictions classify substituted cathinones/pyrrolidinophenones or their analogs as controlled or analogue substances—verify legal status before acquiring, storing, or studying the material.

• Handling & disposal: Use fumehoods, gloves, eye protection, and follow institutional hazardous chemical handling procedures. Waste must be disposed of per hazardous chemical regulations.

• Emergency: Institutions should have SOPs for exposure, spills, and accidental release; contact occupational health or poison control as appropriate.

If you’d like, I can:

• provide non‑actionable references to peer‑reviewed papers and forensic method papers that describe analytical characterization of pyrrolidinophenones;

• draft safety/disclaimer copy or a COA template suitable for a regulated lab catalogue; or

• create an analytical data checklist (tests to run: NMR, MS, HPLC, residual solvents, etc.) for legitimate forensic/analytical QC purposes.

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