🔬 1P-LSD – Research-Grade Lysergamide for Scientific Use Only
1P-LSD (1-Propionyl-D-lysergic acid diethylamide) is a psychedelic research chemical belonging to the lysergamide family, closely related to LSD-25. It features a propionyl group attached to the indole nitrogen of the LSD molecule, making it a prodrug that may metabolize into LSD in biological systems—though its effects and pharmacology may differ slightly.
1P-LSD is widely used in laboratory research to study serotonergic pathways, 5-HT2A receptor activity, and psychedelic pharmacodynamics. It is popular among researchers due to its chemical stability, legal grey area in certain jurisdictions, and its ability to serve as a functional analogue to LSD for non-human trials and forensic analysis.
Available in blotter, pellet, or powder form, 1P-LSD is intended strictly for analytical and forensic research purposes only. It is not approved for human consumption and should be handled with appropriate laboratory safety protocols.
⚠️ Legal & Safety Disclaimer:
1P-LSD is sold strictly for research purposes and is not intended for human or veterinary use. Always consult local laws before purchase, as the legal status of 1P-LSD may vary by country or region. Handle in controlled environments using appropriate safety equipment.
📈 SEO Keywords:
-
1P-LSD research chemical
-
Buy 1P-LSD for lab use
-
Lysergamide compound for research
-
Legal LSD analogue 2025
-
Psychedelic research chemicals
-
5-HT2A receptor study compounds
-
Analytical grade 1P-LSD
-
Forensic psychedelic chemical
Would you like this rewritten for a B2B lab supplier site, a compliance-focused page, or in a fact sheet format? Let me know your audience or platform needs.
✅ How 1P-LSD Is Consumed (Informational Purposes Only)
1P-LSD (1-Propionyl-LSD) is a psychedelic lysergamide compound often studied for its similarity to LSD-25, with comparable effects and pharmacology in non-clinical research. In places where research on human bioactivity is legal or permitted under regulated settings, it has been observed that 1P-LSD is typically administered via the following routes of administration:
🔹 1. Sublingual Administration (Under the Tongue)
-
Blotters or tabs containing 100–150 mcg are placed under the tongue
-
Held for 20–30 minutes before swallowing
-
Absorption occurs through the mucous membranes, bypassing digestion
-
This is the most commonly reported method for psychedelic lysergamides
-
Onset: 30–90 minutes | Duration: 8–12 hours (anecdotally)
🔹 2. Oral Ingestion
-
Tabs or liquid solutions are swallowed directly
-
Absorbed through the gastrointestinal tract
-
Slightly longer onset than sublingual (45–90 minutes)
-
Metabolized into LSD in the liver via hydrolysis of the propionyl group
🔹 3. Volumetric Dosing (for precision)
-
Distilled in alcohol or distilled water (e.g., 100 mcg per 1 mL)
-
Measured using syringes or droppers for accurate microdosing or research
-
Stored in amber glass bottles in cool, dark environments
⚠️ Important Notes for Researchers:
-
Always use gloves, safety glasses, and proper ventilation when handling 1P-LSD
-
1P-LSD is photosensitive and should be kept away from heat and light
-
Dosage should be calculated precisely, as it is active at microgram levels
-
Legal status varies—verify local laws before acquiring or studying
📈 SEO Keywords:
-
How to dose 1P-LSD
-
1P-LSD administration methods
-
Sublingual vs oral 1P-LSD
-
Volumetric dosing research chemicals
-
Legal LSD analogues usage
-
Psychedelic dosing safety
-
Research chemical best practices
If you’re working on a scientific paper, compliance-focused content, or need help creating a fact sheet for lab use, I can help format this accordingly. Let me know your intended audience.
✅ 1P-LSD: Uses, Properties, and Manufacturing Process
🔬 A Lysergamide Analog of LSD Used in Scientific and Analytical Research
🔹 What is 1P-LSD?
1P-LSD (1-propionyl-lysergic acid diethylamide) is a semi-synthetic lysergamide compound closely related to LSD-25. It contains a propionyl group attached to the nitrogen of the indole ring, making it a prodrug to LSD. Under certain conditions, 1P-LSD may convert into LSD in the body, although this behavior is the subject of ongoing research.
📘 Uses of 1P-LSD (for Research Purposes Only)
1P-LSD is not approved for human consumption and is sold solely for scientific, forensic, and analytical research. It is used in in vitro, animal studies, and receptor-binding assays.
🔬 Common Research Uses:
-
Studying 5-HT2A receptor agonism and serotonergic activity
-
Structure-activity relationship (SAR) research on lysergamide analogs
-
Pharmacokinetics and metabolic profiling
-
Comparison studies between LSD analogs
-
Legal alternative to LSD in jurisdictions where permitted
⚠️ Legal Note:
While 1P-LSD has been sold as a legal alternative to LSD in some regions, it may be considered an analog under analogue acts or controlled by specific scheduling. Always verify the legality in your country or region.
🧪 Chemical Properties of 1P-LSD
Property | Details |
---|---|
Chemical Name | 1-Propionyl-D-lysergic acid diethylamide |
Molecular Formula | C23H29N3O2 |
Molecular Weight | 379.50 g/mol |
Structure | Lysergamide backbone with a propionyl group |
Appearance | Crystalline powder or impregnated on blotter |
Potency | Approx. equivalent to LSD-25 (by mass) |
Solubility | Soluble in ethanol, water (limited), acetone |
Stability | Light- and heat-sensitive; degrades slowly |
🏭 Manufacturing Process of 1P-LSD (Educational Summary Only)
The synthesis of 1P-LSD is a complex, multi-step organic chemistry process, typically performed by trained chemists in licensed facilities. It involves the modification of lysergic acid derivatives, which are controlled in many jurisdictions. This outline is for educational understanding only and not a how-to guide.
🔬 Step-by-Step Overview:
🔹 1. Lysergic Acid Preparation
-
Derived from ergot alkaloids (from Claviceps purpurea fungus)
-
Alternatively synthesized from ergine (LSA) found in morning glory seeds or HBWR
-
Converted into lysergic acid hydrazide via hydrolysis and purification
🔹 2. LSD Synthesis
-
Lysergic acid is activated using reagents (e.g., phosphoryl chloride)
-
Reacted with diethylamine to yield LSD-25
🔹 3. 1P-LSD Synthesis
-
LSD is reacted with propionyl chloride or another propionyl donor
-
This attaches the propionyl group at the indole nitrogen (N1 position)
-
Result: 1-Propionyl-LSD (1P-LSD), a structural analog of LSD
-
Final product is purified using chromatography and crystallization
🔹 4. Formulation & Packaging
-
Dissolved in ethanol or applied to blotter paper (typically 100 mcg per tab)
-
Alternatively stored as a powder or volumetrically dosed solution
-
Packaged in light-proof, air-tight containers to preserve stability
⚠️ Manufacturing Safety Notes:
-
The process involves controlled substances, corrosive reagents, and highly sensitive reactions
-
Should only be carried out in licensed chemical laboratories
-
Unauthorized synthesis is illegal and extremely dangerous
📈 SEO Keywords:
-
What is 1P-LSD
-
1P-LSD synthesis overview
-
Research chemical LSD analog
-
1P-LSD legal status
-
Properties of 1P-LSD
-
How 1P-LSD is made
-
Lysergamide research chemicals
-
1P-LSD vs LSD comparison
-
Serotonergic receptor compounds
-
Analytical research with 1P-LSD
Reviews
There are no reviews yet.